Tag: 上海楼凤


More new bookings equal more bonuses with new Sandals Resorts incentive


first_img Travelweek Group << Previous PostNext Post >> Tuesday, January 23, 2018 Share More new bookings equal more bonuses with new Sandals Resorts incentivecenter_img TORONTO — Agents can earn up to US$85 for every new booking with a just-released booking incentive bonus from Sandals Resorts – and there’s no limit to how much agents can earn.The bonus is “in appreciation of the continued support from the travel agent community [and] just in time for the all-important winter season,” says Sandals Resorts.Effective immediately, agents who book their clients now through March 15, 2018 (and for travel anytime) will receive a bonus payment, based on length of stay and room category for each new booking:Butler SuiteUS$35 bonus for 6-night stayUS$85 for 7 nights or moreClub / Concierge SuiteUS$25 bonus for 6-night stayUS$55 for 7 nights or moreLuxury / Deluxe RoomUS$15 bonus for 6-night stayUS$30 for 7 nights or moreAll bookings must be registered on Sandals’ travel agent portal taportal.sandals.com within 30 days of making the booking.The incentive booking bonus payments will be made within 10-14 business days after travel.More news:  Air Canada’s global sales update includes Managing Director, Canada & USA SalesFor more information, travel agents are asked to contact their local Business Development Manager, call Inside Sales at 1-800-545-8283 or visit taportal.sandals.com. Tags: Agent Incentives, Sandals Resorts Posted bylast_img read more


Rep Kahle announces consumer education presentation


first_img26Jan Rep. Kahle announces consumer education presentation Categories: Kahle News State Rep. Bronna Kahle announced that the attorney general’s office will conduct consumer education presentations in Lenawee County. The senior seminar will offer an identity theft presentation teaching the signs of identity theft, how to protect personal information online and off, and what to do if you become a victim.“This is a great opportunity for seniors to learn how to avoid becoming a victim of identity theft and how to minimize the impact on your life when you’ve been targeted,” Rep. Kahle said. “I’m happy to work with the attorney general’s office to provide this vital information.”The seminars will take place on Friday, Feb. 2 at the following locations:Hudson Senior Center from 10 to 11 am; andAdrian Senior Center from 12:30 to 1:30 pm.RSVPs are not required and there is no cost to attend. For more information, please contact Rep. Kahle’s office at (517) 373-1706 or BronnaKahle@house.mi.gov.last_img read more


French telco Orange and telecomstoconstruction c


first_imgFrench telco Orange and telecoms-to-construction conglomerate Bouygues are open to including the latter’s 44% interest in leading commercial broadcaster TF1 in any deal between the pair, according to French newspaper Le Monde.Orange and Bouygues have confirmed that they are in talks over the future of the latter’s telecom unit, Bouygues Telecom, but have not mentioned Bouygues stake in TF1.According to Le Monde, citing unnamed sources, Orange and Bouygues are open to the idea of Orange taking a stake in TF1 of around 10%.Orange CEO Stéphane Richard told TV station RTL that convergence between telecoms and content in general was again coming to the fore. He said that while there was a need “to leave the door open” on this topic, it was not on the agenda “for the moment”.A deal over TF1 could be controversial because the French state retains a 24% stake in Orange.French economy minister Emmanuel Macron told journalists earlier this week that the French state plans to remain a key shareholders in the telco and will assess a deal over Bouygues Telecom with consumer protection, jobs and investment in mind.last_img read more


The Noose Around Your Wealth Is Tightening O


first_img The Noose Around Your Wealth Is Tightening Out-of-control taxes… investment controls… predatory lawsuits… the risks to your capital are growing by the day. And the unfortunate truth is the more of your wealth you have in your home country, the greater the risk. That’s why it’s critical to internationalize as much of your hard-earned assets as you can – as fast as possible. Going Global 2013 will help you do just that. Featuring investment experts Doug Casey, Peter Schiff, Mike Maloney, and more, this must-see webinar will reveal offshore strategies you can easily implement to protect what’s rightfully yours. Click here for details. The silver price was much more ‘volatile’, as it traded in a two percent price range through Far East and London trading.  It also had the New York rally at the same time as gold…and it ended at the same time as gold, just before 11:00 a.m. EDT. According to Kitco, the high at that point was $22.13 spot, but got sold down back below the $22 spot price almost immediately. Silver closed at $21.79 spot…up 11 cents from Tuesday’s close.  Net volume was very light at only 22,000 contracts. (Click on image to enlarge) Maybe the 20-day moving average is being defended…but I’m speculating on that one. However, as I’ve mentioned on countless occasions, the dollar index is not much of a factor as far as the precious metals are concerned…and if there is much correlation, it’s usually when the index is rallying, as it becomes a cover for “da boyz” as they hit the p.m. prices…and the main stream media is always quick to jump on that particular bandwagon.  And as you can see lately, even though the dollar index is down sharply, the precious metals aren’t up at all…as there’s always a seller of last resort waiting in the wings the moment that occurs…the last three trading days being a case in point. I note in overnight trading in the Far East, that the Japanese stock markets got crushed for over 6 percent…and gold and silver’s attempts to break above the $1,400 and $22 price ceilings ran into a seller of last resort around 11:00 a.m. Hong Kong time on their Thursday morning.  After that, they both traded flat into the London open. But once London began to trade, all four precious metals got sold down a bit…and all are trading below their New York closes yesterday as I hit the ‘send’ button on today’s column at 5:10 a.m. EDT. Volumes are pretty decent in gold and silver already.  The dollar index is down another 21 basis points. That’s it for another day…and I’ll see you here tomorrow. The gold stocks rallied right from the open…and at their high of the day, just before noon in New York, they were up 2.5 percent…but then faded [along with the gold price] as the trading day progressed…and the HUI finished up only 0.91%. Another day when there aren’t that many stories…and I hope there a few in here that catch your eye. [The] gold mining industry, for the most part, is dumber than the rocks it digs out of the ground.  Too dumb to defend itself, purporting to be represented by the World Gold Council, which exists only to make sure that there never is a real world gold council. – Chris Powell, GATA…04 April 2013 It was another day where there wasn’t much volume…and not a lot of price action either.  However, it’s obvious the $1,400 price mark in gold…and $22 silver is still being vigorously defended.  By whom…and for what reason…is unknown. There’s certainly a scarcity of gold and silver-related stories at the moment…and I even checked some of the websites myself and there was nothing.  The only event of any importance coming up is the COT Report tomorrow…a lifetime away at the moment. I’ve noted that since the dollar index high/gold-silver low of May 20th, the dollar index has declined from 84.3 down to 80.7…and the gold price has been capped at the $1,400 mark…and every close above that price, no matter how brief, has been sold down to below the $1,400 price ceiling. During that dollar index decline of 370 basis points…4.4 percent…the gold price has not been allowed to reflect that decline…and is basically trading unchanged from its May 20th price.  Here’s the 30-day dollar index chart. It’s obvious the $1,400 price mark in gold…and $22 silver is still being vigorously defended. The gold price did nothing in the Far East and most of the London trading day on their Wednesday.  The New York low came at the 9:30 a.m. EDT open of the equity markets, just like it has for the last three days in a row. The subsequent rally got cut off at the knees shortly before 11:00 a.m. in New York…and a few minutes before the London close…just as it was about to get a sniff of the $1,400 price mark.  The high tick at that point was $1,395.80 spot.  From there it traded sideways into the Comex close…and then got sold down a bit in the New York Access Market. The gold price closed at $1,388.40 spot…up $10.20 on the day.  Gross volume wasn’t overly heavy at 121,000 contracts. But the silver stocks finished slightly in the red…as Nick Laird’s Intraday Silver Sentiment Index closed down 0.19%. Here’s the 30-day gold chart, with the 20 and 50-day moving averages shown. (Click on image to enlarge) The CME’s Daily Delivery Report was another non-event on Wednesday, as only 3 gold and 17 silver contracts were posted for delivery within the Comex-approved depositories on Friday. We’re getting on in the June delivery month, so unless there are some big surprised between now and June 30th, we shouldn’t expect big deliveries, as most are done within the first week of the delivery month. There were no reported changes in either GLD or SLV yesterday…and there was no sales report from the U.S. Mint, either. Over at the Comex-approved depositories on Tuesday, they reported receiving 99,690 troy ounces of silver…and didn’t ship any out.  The link to that activity is here. In gold on Tuesday, these same depositories didn’t report receiving any, but did ship out 45,371 troy ounces of the stuff…all out of Brink’s, Inc.  The link to that activity is here. No charts or graphs again today…but here’s your ‘cute quota’… Sponsor Advertisement It was obvious to me that if a willing seller hadn’t shown up in the Comex gold and silver markets just before 11:00 a.m. in New York, both metals would have closed materially higher. The dollar index closed at 81.05 late on Tuesday afternoon…and began to rally slightly right from the open in Far East trading on their Wednesday morning.  The high tick of the day…81.30…came at 8:00 a.m. EDT right on the button. From there it got sold down to its low tick…80.78…which came just before noon in New York.  The subsequent rally didn’t make it back above the 81.00 level…and closed at 80.91…down 14 basis points on the day.last_img read more


After a middle school student brought a gun to sch


first_imgAfter a middle school student brought a gun to school amid several other school shooting threats made in Tuscaloosa last week, a Tuscaloosa City School Board member said she’s taking action.Erica Grant, who represents District 5, organized a prayer event Sunday at each Tuscaloosa City School. Scheduled for 4:13 p.m., the time is symbolic of Philipians 4:13. Gatherers prayed for the violence to stop.“I just think besides charging teachers and blaming this person or that person, we have got to take this stuff into our own hands and pray and work, because faith without work is dead,” Grant said.There’s a meeting tonight on the issue at Plum View Baptist Church in Tuscaloosa.last_img


Iowas Massive Bird Flu Outbreak Prompts Mexico to Ban Imported Poultry Eggs


first_img April 22, 2015 Reuters –shares Add to Queue Register Now » Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Iowa’s Massive Bird Flu Outbreak Prompts Mexico to Ban Imported Poultry, Eggs Mexico, the biggest buyer of U.S. chicken, has halted imports of live birds and eggs from the U.S. state of Iowa due to an outbreak of deadly bird flu there, the Mexican government said on Tuesday.Mexico and other major countries last month imposed new export restrictions on poultry products from various U.S. states, but a new outbreak has hit top U.S. egg-producing state Iowa.Iowa found a lethal strain of bird flu in millions of hens at an egg-laying facility on Monday, the worst case so far in a national outbreak that prompted Wisconsin to declare a state of emergency.Bird flu, also called avian influenza or AI, is a viral disease that infects birds. Officials believe wild birds are spreading the virus but they do not know how it is entering barns.Shares of several leading meat companies’ in the United States fell on Tuesday on concerns over the Iowa outbreak.Mexico’s agriculture ministry said it and animal health body SENASICA had tightened controls and monitoring of migratory wild birds, and it said they were in constant contact with bird farms in Mexico to detect any suspicious cases domestically.The ministry emphasized that Mexico is self sufficient in the production of eggs for consumption, and that Mexican producers import fertilized eggs used for breeding.Iowa was already among 12 states that have detected bird flu in poultry since the beginning of the year. The other states are Arkansas, Idaho, Kansas, Minnesota, Missouri, Montana, North Dakota, Oregon, South Dakota, Washington and Wisconsin.center_img Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals 2 min read Next Article Food Image credit: threeboydad | Foap This story originally appeared on Reuterslast_img read more


New study uncovers key protein in the production of insulin


first_imgReviewed by Kate Anderton, B.Sc. (Editor)Jan 25 2019The crucial hormone insulin needs help acquiring the right structure. A protein that assists in the process of insulin folding has just been discovered in a new study conducted by researchers at the Department of Biomedical Sciences, University of Copenhagen. They hope the new research results can be used to develop treatments for conditions such as increased level of insulin in the blood known as hyperinsulinemia.Even though researchers have been familiar with and studied the hormone insulin for more than a hundred years, especially in connection with diabetes, they still make new discoveries concerning the hormone. Now researchers from the Faculty of Health and Medical Sciences at the University of Copenhagen have uncovered a hitherto unknown process in the production of insulin. The new research results have just been published in the scientific journal Diabetes.Insulin is produced in the beta cells of the pancreas. The hormone is produced as a precursor called proinsulin. For proinsulin to mature into functional insulin, it needs to be folded and processed correctly to acquire the right structure with assistance from proteins that are termed chaperones. The researchers have now discovered and identified such a chaperone. A proinsulin chaperone termed glucose-regulated protein GRP94.’Even though proinsulin has a relatively short sequence, it still needs help acquiring the right structure to become mature, functional insulin. However, several other studies have shown that proinsulin can be folded without help from proteins in artificial cell-free conditions. Yet, our study conducted in live cells shows that proinsulin is not folded correctly and does not acquire the right structure without help from GRP94,’ says last author of the study, Associate Professor Michal Tomasz Marzec from the Department of Biomedical Sciences at the University of Copenhagen.Impaired Insulin Production and SecretionIn the study the researchers removed or inhibited the protein GRP94 in to see what happened with the proinsulin and the cells. They observed that the proinsulin was not folded correctly and the beta cells did not secrete sufficient amounts of insulin. The researchers were surprised though to learn that removal of GRP94 did not affect cell viability. Nothing happened to the cells after they had removed the protein.Related StoriesVirus killing protein could be the real antiviral hero finds studyRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalStudy reveals how protein mutation is involved in Christianson syndrome’This is surprising, because one would anticipate that the beta cells would die from stress when huge amounts of misfolded proinsulin accumulate inside the cells. It is like removing the bearing beam without weakening the construction. This indicates that the GRP94 protein plays a very specialized function and that beta cells are well-prepared to mount effective responses to deal with consequences of misfolding of proinsulin. We are currently working to understand these responses and their biological and pathological consequences,’ says Associate Professor Michal Tomasz Marzec.According to the researchers, the research results may make it possible in the future to manipulate the process from proinsulin to insulin in the body’s beta cells. If you can use medicine to inhibit the assistant protein, the result would be reduced insulin secretion. This would be useful in connection with conditions like hyperinsulinemia, where the body produces too much insulin. In the long term, they also hope the new knowledge will be useful in connection with types 1 and 2 diabetes.’We hope this new discovery will guide the development of novel drugs. Understanding the biological processes behind the production of insulin in the cells will enable us to modify the processes. We thus hope we will be able to inhibit overproduction of insulin as it occurs in children and adults with hyperinsulinemia. In the long term we also hope we will be able to increase the production of insulin, ease the large production burden of beta cells in connection with type 2 diabetes and to maintain their secretion function for longer without the need for insulin injections,’ says Associate Professor Michal Tomasz Marzec. Source:https://healthsciences.ku.dk/newsfaculty-news/2019/01/researchers-discover-key-protein-in-the-production-of-insulin/last_img read more


Data scandal threatens Zuckerberg vision for Facebook


Citation: Data scandal threatens Zuckerberg vision for Facebook (2018, March 20) retrieved 18 July 2019 from https://phys.org/news/2018-03-scandal-threatens-zuckerberg-vision-facebook.html “If the business model is predicated on selling user data, it can seem as democratic as you want but it’s serving a surveillance function that undermines democratic values,” Young said. Facebook CEO Mark Zuckerberg is seen in 2013 explaining his mission “to make the world more open and connected” Mark Zuckerberg’s ambitious vision for Facebook spawned one of the world’s most powerful companies, but he now faces a moment of reckoning as it becomes clear the social network has been hijacked and manipulated for very different ends.Snowballing revelations on the misuse of the Facebook platform to spread disinformation, and to harvest personal data in ways users had never imagined, risks undermining the very business model underpinning the social media giant.Zuckerberg took an idea hatched in his Harvard dormitory and created a network connecting more than two billion people, crushing competing social networks while imagining new ways to connect friends to each other—and for marketers to reach users.The rise of social media fuelled a wave of optimism about empowering ordinary people, notably following the Arab Spring uprisings starting in 2010.”I had the feeling in 2011 that digital technologies were inherently democratic and would fuel democratic revolutions around the globe,” said Dannagal Young, a University of Delaware professor who studies social media.Young said these networks did indeed help propel the Arab Spring, as well as social movements like Black Lives Matter or #MeToo—but that the public had failed to grasp their darker side.”People use these platforms and do not understand the economic model,” Young said.”They don’t understand what is being commodified, as is everything they do and everything they share.”Eliminating gatekeepersWhile social networks appear to empower individuals by doing away with “gatekeepers”—such as the traditional mass media, or political authorities—the selling of user data can have the opposite effect. First it was “move fast and break things.” Then it was “connecting the world” and “building a global community.” Facebook’s reputation has been tarnished ever since 2016, following disclosures of Russian-led efforts to influence the US election—notably by spreading “fake news” and other forms of disinformation on social media.But things got markedly worse following weekend revelations that data on 50 million users was culled by a British-based political firm working on Donald Trump’s presidential campaign, prompting calls for investigations on both sides of the Atlantic.Zuckerberg, who began touring the United States after the presidential election, sparking speculation he might run for top office, last year offered his vision of a “global community” as more people become disillusioned with troubled political institutions.”The world feels anxious and divided, and Facebook has a lot of work to do,” the 33-year-old wrote.But first of all, Zuckerberg will need to focus on the more immediate mission he set himself earlier this year: to “fix” his embattled social network.’Polluted by bad actors’Roger Kay, a technology analyst and consultant for Endpoint Technologies Associates, noted that Facebook is just one of many online firms that make use of detailed digital records on its users’ activities, which can rarely be expunged.”Facebook adds to this, but it’s not the cause of the problem,” Kay said. “The problem is your long-term digital footprint.”Young, of the University of Delaware, voiced optimism that users can regain better control over their Facebook data—as more people learn about online privacy and how to determine what is shared about them.”We as users have a lot more control than we think,” she said. Explore further “If enough users go in and change their settings Facebook will be forced to respond. I do think there is a fix but it requires a whole lot of learning.”Then comes the issue of disinformation—which Facebook has been under mounting pressure to combat.Emily Vraga, a George Mason University professor of communication, said Facebook has taken positive steps in ferreting out false information in recent months.”But I would like to see even more of that,” she said.One way, she said, would be making Facebook’s algorithm available.”I do think the public should be more aware” of how the network operates, she said.For Young, both Facebook and Zuckerberg appear to have assumed that “when you crowdsource things the truth will come out”—a belief that appears naive in light of the “fake news” phenomenon.”It could be that 98 percent of people on Facebook do it in good faith,” she said, but “it doesn’t take a lot to undermine that system.”Kay also voiced doubt over Facebook’s ultimate ability to eliminate all malicious content without examining every item on its platform—an impossible task.”They can’t curate something with two billion users, there aren’t enough editors out there,” he said. “And if they held up the content, the users would go away.”He also notes that Facebook is not the first digital firm to be manipulated in such a way.”Social networks have come and gone,” Kay said. “They are first seen as an amazing way to connect people and then they become polluted by bad actors.” UK lawmaker: Facebook misled Parliament over data leak risk Mark Zuckerberg said this year his mission is to “fix” the problems of the social network © 2018 AFP Facebook “likes” are part of data profiles which can be scraped by marketers and others This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. read more


Startup creates printer that makes customized medicines for pets


first_imgA startup is using Purdue University-patented technology to produce precise, customized medicine for pets. Arun Giridhar is one of the co-founders of Pinpoint Pharma, a precision compounding pharmacy for veterinarians. Pinpoint Pharma has created a printer that is faster than traditional methods of making customized medicine that is tailored to each individual animal’s needs. Credit: Purdue Research Foundation image/Oren Darling Provided by Purdue University Pinpoint Pharma has created a device similar to an inkjet printer that can precisely dispense pharmaceuticals to meet a growing need for customized medication for pets. Credit: Purdue Research Foundation image/Oren Darling While it can take more than an hour to produce a batch of 100 to 300 capsules, Pinpoint Pharma’s printer cuts the total time per patient to 10 minutes, including cleanup, and is flexible on the product form suited to the individual pet.”We can make about one dose every second, or even faster,” Giridhar said. The printer also is more precise, using a tracking mechanism to record how many drops of medicine are dispensed in each dose and the volume of each drop, in real time. Typically making a batch of pills can have variances in potency between doses, Giridhar said.The printer also helps make potent medications that have a narrow therapeutic index, where small differences in dose concentration can lead to serious therapeutic failures or adverse drug reactions.”In such cases, it becomes important to dose very precisely,” Giridhar said.Giridhar said what sets Pinpoint Pharma apart is that the team has more experience in this field and the company has worked with a wide variety of medications.Earlier this year, the startup was chosen by gener8tor, a nationally ranked accelerator based in Milwaukee, for its gBETA program, a seven-week accelerator for early-stage companies with local roots. Pinpoint Pharma was one of five startups selected from 52 applicants for the inaugural Indiana cohort; gener8tor also operates programs in Wisconsin, Michigan, Ohio and Minnesota. The program provides mentors, advice on business models and suggestions on ways to grow. It also gives the startups office space and up to $1 million in deals and perks from vendors.”Our experience with gBETA has helped Pinpoint Pharma move forward with our business model and develop new relationships with customers, mentors and investors,” Giridhar said. Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Researchers commercialize drug dosage printer to improve personalized medicine production, cut side effects Pinpoint Pharma has created a printer that is faster than traditional methods of making customized medicine. The company is among three startups receiving assistance from the Purdue Foundry and eight startups from Indiana that will be featured Sept. 5-7 at the TechCrunch Disrupt SF Conference in San Francisco.Pinpoint Pharma is a precision compounding pharmacy for veterinarians, ensuring that the medicine tailored to each individual animal’s needs is easier for pet owners to give and for pets to take, which optimizes clinical outcomes.Arun Giridhar, Pinpoint Pharma’s chief executive officer, and three faculty members of Purdue’s Department of Industrial and Physical Pharmacy and Davidson School of Chemical Engineering founded Pinpoint Pharma two years ago, and have been joined recently by Angela Demaree, a nationally known veterinarian, who received her DVM from Purdue. The goal was to create a device like an inkjet printer that could precisely dispense pharmaceuticals to meet a growing need for customized medication for pets instead of a one-size-fits-all approach generally taken.”When a pet has a specific requirement as determined by their vet, we can dispense the exact amounts and ratios of active ingredients needed for a pill, in a form and flavor that the specific pet will love,” Giridhar said.For pets, the one-size-fits-all method doesn’t always work.”Our medicine printer allows veterinarians to be very precise in serving an animal as an individual rather than as the average of a population.”Giridhar said Pinpoint Pharma’s medicine printer has two advantages over other methods used to make customized drug products: it is faster and more precise. Citation: Startup creates printer that makes customized medicines for pets (2018, September 5) retrieved 17 July 2019 from https://phys.org/news/2018-09-startup-printer-customized-medicines-pets.htmllast_img read more


Conspiracy to name Sonia in AgustaWestland case Congress


first_imgSHARE Matter may rock Parliament on Friday The Congress on Thursday attacked the Centre over a reported statement made by the counsel of Christian Michel, an accused in the AgustaWestland case, that the Narendra Modi government and its agencies were forcing him to sign a false confessional statement naming UPA chairperson Sonia Gandhi in return for exoneration from charges.The allegation is set to rock the Monsoon Session of Parliament, which is about to take up a no-confidence motion against the Centre on Friday.The Congress’ media in-charge Randeep Singh Surjewala termed the revelations as stunning and said they had blown the lid off the “concerted conspiracy”, “blind vendetta” and “web of lies” weaved by Modi against the Congress leadership. “Even as Christian Michel has been detained in Dubai, Indian agencies have failed to produce any evidence in the courts so far and are merely involved in hatching a conspiracy against leaders of Opposition and using Christian Michel as a tool for the purpose,” Surjewala said in a statement on Thursday.“Never before in the history of India has a Prime Minister been found complicit in gaining ‘false evidence’ against Opposition leaders to seek revenge. This shocking expose is also a testimony to the disease prevailing in CBI/ED prostrating before the Prime Minister to collect fake and false evidence with a single handed aim of tarnishing the reputation of Opposition leaders and serving the political masters as a ‘captive puppet’ and a ‘willing tool’ of malicious conspiracy,” he said. July 19, 2018 SHARE SHARE EMAIL Former Congress president and UPA Chairperson Sonia Gandhi   –  PTI corruption & briberycenter_img Published on COMMENT national politics COMMENTSlast_img read more